Tomoya Sakabe Selected Research

N- (3- (5- (4- bromo- 2- fluorophenylamino)- 3- cyclopropyl- 8- methyl- 2,4,7- trioxo- 3,4,7,8- tetrahydro- 2H- pyrido(2,3- d)pyrimidin- 1- yl)phenyl)methanesulfonamide

8/2010

A novel MEK1/2 inhibitor induces G1/S cell cycle arrest in human fibrosarcoma cells.

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Tomoya Sakabe Research Topics

Disease

7	Neoplasms (Cancer) 05/2013 - 09/2006
6	Osteosarcoma (Osteogenic Sarcoma) 07/2010 - 09/2006
2	Tendon Injuries 06/2011 - 01/2011
2	Margins of Excision 01/2011 - 06/2008
2	Fibrosarcoma 08/2010 - 07/2010
1	Giant Cell Tumor of Tendon Sheath 05/2013
1	Acquired Immunodeficiency Syndrome (AIDS) 05/2013
1	Chondrosarcoma 10/2012
1	Surgical Wound 10/2012
1	Ewing Sarcoma (Sarcoma, Ewing) 01/2011
1	Necrosis 01/2011
1	Bone Resorption 07/2010
1	Neoplasm Metastasis (Metastasis) 02/2009
1	Synovial Sarcoma (Synovioma) 06/2008
1	Femoral Neck Fractures 05/2006
1	Hip Fractures (Intertrochanteric Fractures) 05/2006

Drug/Important Bio-Agent (IBA)

3	Zoledronic Acid (Zometa)FDA Link 07/2010 - 02/2009
2	Diphosphonates (Bisphosphonates)IBA 07/2010 - 07/2010
2	Antineoplastic Agents (Antineoplastics)IBA 07/2010 - 07/2010
2	sulforaphaneIBA 11/2007 - 09/2006
1	Thallium-201IBA 05/2013
1	GadoliniumIBA 05/2013
1	HemosiderinIBA 05/2013
1	TitaniumIBA 10/2012
1	Transforming Growth Factors (Transforming Growth Factor)IBA 06/2011
1	AK 2123IBA 01/2011
1	Intercellular Signaling Peptides and Proteins (Growth Factors)IBA 01/2011
1	CytokinesIBA 01/2011
1	N- (3- (5- (4- bromo- 2- fluorophenylamino)- 3- cyclopropyl- 8- methyl- 2,4,7- trioxo- 3,4,7,8- tetrahydro- 2H- pyrido(2,3- d)pyrimidin- 1- yl)phenyl)methanesulfonamideIBA 08/2010
1	Mitogen-Activated Protein Kinase Kinases (MEKs)IBA 08/2010
1	Docetaxel (Taxotere)FDA Link 07/2010
1	Etoposide (VP 16)FDA LinkGeneric 07/2010
1	Fluorouracil (Carac)FDA LinkGeneric 07/2010
1	Gemcitabine FDA Link 07/2010
1	Doxorubicin (Adriamycin)FDA LinkGeneric 07/2010
1	Paclitaxel (Taxol)FDA LinkGeneric 07/2010
1	Cisplatin (Platino)FDA LinkGeneric 07/2010
1	Vascular Endothelial Growth Factor A (Vascular Endothelial Growth Factor)IBA 02/2009
1	Proteins (Proteins, Gene)FDA Link 11/2007
1	AlkaloidsIBA 10/2007
1	cryptolepineIBA 10/2007
1	Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)IBA 09/2006
1	LigandsIBA 09/2006

Therapy/Procedure

3	Drug Therapy (Chemotherapy) 08/2010 - 11/2007
2	Myocutaneous Flap 10/2012 - 01/2011
2	Radiotherapy 01/2011 - 06/2008
2	Therapeutics 07/2010 - 09/2006
1	Renal Dialysis (Hemodialysis) 05/2006